This collection of models was assembled as an exemplary starting point for parameter balancing. They are
mainly taken from the BioModels Database, others taken from chosen publications. Please note that these
models are not altered from their original state in order to make them more compliant to the parameter
balancing procedure. As stated in the FAQ, parameter balancing does not work well with, e.g., biomass
reactions, transport reactions, or enzymes that are modelled as species (instead of parameters). Furthermore,
if modifiers lack characterising SBO terms, they cannot be identified as either catalyst or inhibitor. If
you properly want to employ the models below for parameter balancing, it is advisable to keep these remarks in mind.
The corresponding parameter collections are mainly supposed to exemplify the data format SBtab. Their origins are
given in the file itself. They are by no means considered to be exhaustive.
Phosphofructokinase Reaction (PFK)
Our SBML model of the Phosphofructokinase reaction was constructed
from the KEGG
Reaction
R04779
with
semanticSBML-fill.
Glycolysis (Teusink et al, 2000)
Teusink's glycolysis model (
Teusink et al, (2000))
has been assembled from enzymatic rate laws determined in vitro.
Glycolysis model (Hynne et al., 2001)
Hynne's glycolysis model (
Hynne et al., 2001) was created to describe glycolysis in yeast at
the onset of metabolic oscillations. In the encoded version from
BioModels Database, SBO terms for allosteric inhibitors are
missing. We provide a second version in which these SBO terms have
been added.
Pancreatic Beta Cell Model (Jiang et al.,2007)
Jiang's model of the glucose-stimulated secretion system in
pancreatic beta cells (
Jiang
et al.,2007) is one of the largest kinetic models in BioModels Database.
E coli central metabolism
Additional data files concerning E. coli central metabolism can be found
here.
A collection of transformed standard Gibbs free energies of reaction
The collection is an extract of the
eQuilibrator project and was kindly provided by Elad Noor. It can be downloaded
here.